Directions From Downtown Tampa To 3421 E Powhatan Ave, Tampa, Fl 33610 Starting Point: Downtown Tampa (E.G., 100 W Kennedy Blvd, Tampa, Fl 33602) Destination: 3421 E Powhatan Ave, Tampa, Fl 33610 Distance: Approximately 5.5 Miles Estimated Travel Time: 10-15 Minutes (Depending On Traffic) Driving Directions: Head East On W Kennedy Blvd Toward S Tampa St. Turn Left Onto N Tampa St. Continue Onto Tampa St, Which Becomes The Tampa Bay Blvd. Merge Onto I-275 N Via The Ramp Toward I-4. Take Exit 46B For Us-92 E/E Hillsborough Ave. Turn Right Onto Us-92 E/E Hillsborough Ave. Turn Left Onto N 34Th St. Turn Right Onto E Powhatan Ave. Continue On E Powhatan Ave; The Destination, 3421 E Powhatan Ave, Will Be On Your Right.